Signatories of the Nuclear Non-Proliferation Treaty (NPT) have agreed to work towards a nuclear-weapons-free zone in the Middle East.
The members, meeting at the UN in New York, called for a conference in 2012 attended by Middle Eastern states - including Iran - to establish the zone.
The document also said Israel should sign the NPT.
US President Barack Obama backed the deal but said he was "strongly opposed" to Israel being singled out.
The US says the reference could jeopardise efforts to persuade the Israelis to attend the 2012 talks.
The NPT has suffered from deep divisions between states who have nuclear weapons and those who do not, says the BBC's United Nations correspondent Barbara Plett in New York.
It is seen as the cornerstone of global disarmament efforts, she adds.
The 28-page final declaration was agreed following intense talks on the last day of a month-long conference.
The members, meeting at the UN in New York, called for a conference in 2012 attended by Middle Eastern states - including Iran - to establish the zone.
The document also said Israel should sign the NPT.
US President Barack Obama backed the deal but said he was "strongly opposed" to Israel being singled out.
The US says the reference could jeopardise efforts to persuade the Israelis to attend the 2012 talks.
The NPT has suffered from deep divisions between states who have nuclear weapons and those who do not, says the BBC's United Nations correspondent Barbara Plett in New York.
It is seen as the cornerstone of global disarmament efforts, she adds.
The 28-page final declaration was agreed following intense talks on the last day of a month-long conference.
The document calls for the United Nations secretary general to organise a meeting of Middle East states in 2012 to agree to the creation of a "zone free of nuclear weapons and all other weapons of mass destruction".
"All eyes the world over are watching us," said conference president Libran Cabactulan, of the Philippines, as the final text was approved.
Egypt's Maged Abedelaziz, speaking for the Non-Aligned Movement of 118 developing nations, welcomed the decision, saying it was "an important step forward towards the realisation of the goals and objectives of the treaty".
"All eyes the world over are watching us," said conference president Libran Cabactulan, of the Philippines, as the final text was approved.
Egypt's Maged Abedelaziz, speaking for the Non-Aligned Movement of 118 developing nations, welcomed the decision, saying it was "an important step forward towards the realisation of the goals and objectives of the treaty".
Sticking points
Diplomats discussing the proposals had continued talks late into the night on Thursday before resuming on Friday.
One of the sticking points involved Israel, a non-member of the NPT, which is widely believed to have nuclear weapons although it has never admitted to possessing them.
Arab states and Israel's allies had to work hard to find agreement over wording for the proposed nuclear-weapons-free zone.
Correspondents say Arab nations want to put pressure on Israel to relinquish its undeclared nuclear arsenal.
Iran also made a late demand that the five recognised nuclear-armed nations agree to a timetable for negotiating a treaty to abolish their arsenals.
In the final document adopted, no specific timetable is set out but the five states commit to "accelerate concrete progress" towards reducing their nuclear arsenals and to report back on that in 2014.
Iran has faced repeated questions over its own nuclear programme, which the West believes is aimed at making weapons. Iran insists it is solely designed to meet its energy needs.
The NPT has encountered difficulty in coming up with the best method for monitoring suspect nuclear programmes in Iran and North Korea.
The four nations with known or suspected nuclear weapons that are not signatories to the treaty - India, Pakistan, North Korea and Israel - are not covered by any NPT agreement reached.
The NPT conference meets every five years. The last review conference, in 2005, failed to adopt a consensus declaration.
Diplomats discussing the proposals had continued talks late into the night on Thursday before resuming on Friday.
One of the sticking points involved Israel, a non-member of the NPT, which is widely believed to have nuclear weapons although it has never admitted to possessing them.
Arab states and Israel's allies had to work hard to find agreement over wording for the proposed nuclear-weapons-free zone.
Correspondents say Arab nations want to put pressure on Israel to relinquish its undeclared nuclear arsenal.
Iran also made a late demand that the five recognised nuclear-armed nations agree to a timetable for negotiating a treaty to abolish their arsenals.
In the final document adopted, no specific timetable is set out but the five states commit to "accelerate concrete progress" towards reducing their nuclear arsenals and to report back on that in 2014.
Iran has faced repeated questions over its own nuclear programme, which the West believes is aimed at making weapons. Iran insists it is solely designed to meet its energy needs.
The NPT has encountered difficulty in coming up with the best method for monitoring suspect nuclear programmes in Iran and North Korea.
The four nations with known or suspected nuclear weapons that are not signatories to the treaty - India, Pakistan, North Korea and Israel - are not covered by any NPT agreement reached.
The NPT conference meets every five years. The last review conference, in 2005, failed to adopt a consensus declaration.
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